SherbyNet - /page/wikibook/entry.mu

Micron Document

<!DOCTYPE html>

</head>

</h1>

</header>

/* start https://en.wikipedia.org/ */

.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}

/* end https://en.wikipedia.org/ */

</style><div role="note" class="hatnote navigation-not-searchable">For sCO<sub>2</sub>, the phase of carbon dioxide, see <a href="Supercritical_carbon_dioxide" title="Supercritical carbon dioxide">supercritical carbon dioxide</a>.</div>

<table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">SCO2</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q8VCL2%20or%20O43819">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q8VCL2,O43819">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2RLI">2RLI</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class=""><a href="Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/10604">SCO2</a></span>, CEMCOX1, MYP6, SCO1L, SCO2 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, PD-ECGF, TP, Gliostatin, TYMP, ECGF1, TdRPase, SCO cytochrome c oxidase assembly protein 2, synthesis of cytochrome C oxidase 2, MC4DN2</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/604272">604272</a>; <a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:3818630">3818630</a>; <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=68444">68444</a>; <a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCO2">SCO2</a>; <a href="Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000284194">SCO2 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Chromosome_22_(human)" class="mw-redirect" title="Chromosome 22 (human)">Chromosome 22 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 287.03471477596px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 293px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">22q13.33</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">50,523,568 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">50,526,461 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">Chromosome 15 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 246.93084264564px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 252.9px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">15|15 E3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">89,255,840 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">89,258,049 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Human_genome" title="Human genome">Human</a></b></th><th><b><a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000284194">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right uterine tube</li><br><li style="line-height: 137%;">granulocyte</li><br><li style="line-height: 137%;">mucosa of transverse colon</li><br><li style="line-height: 137%;">monocyte</li><br><li style="line-height: 137%;">gingival epithelium</li><br><li style="line-height: 137%;">gonad</li><br><li style="line-height: 137%;">palpebral conjunctiva</li><br><li style="line-height: 137%;">periodontal fiber</li><br><li style="line-height: 137%;">right lobe of liver</li><br><li style="line-height: 137%;">epithelium of bronchus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000091780">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">yolk sac</li><br><li style="line-height: 137%;">blastocyst</li><br><li style="line-height: 137%;">embryo</li><br><li style="line-height: 137%;">duodenum</li><br><li style="line-height: 137%;">colon</li><br><li style="line-height: 137%;">proximal tubule</li><br><li style="line-height: 137%;">right kidney</li><br><li style="line-height: 137%;">muscle of thigh</li><br><li style="line-height: 137%;">jejunum</li><br><li style="line-height: 137%;">morula</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000284194">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005507">copper ion binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015035">protein-disulfide reductase activity</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030016">myofibril</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005759">mitochondrial matrix</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005743">mitochondrial inner membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005739">mitochondrion</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031305">integral component of mitochondrial inner membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006878">cellular copper ion homeostasis</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006825">copper ion transport</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001654">eye development</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008535">respiratory chain complex IV assembly</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045454">cell redox homeostasis</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033617">mitochondrial cytochrome c oxidase assembly</a></li></ul>

</div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=9997&rn=1">9997</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=100126824&rn=1">100126824</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000284194;db=core">ENSG00000284194</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000091780;db=core">ENSMUSG00000091780</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O43819">O43819</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8VCL2">Q8VCL2</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_005138">NM_005138</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001169109">NM_001169109</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001169110">NM_001169110</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001169111">NM_001169111</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001111288">NM_001111288</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001162580">NP_001162580</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001162581">NP_001162581</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001162582">NP_001162582</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_005129">NP_005129</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001104758">NP_001104758</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr22:50523568-50526461">Chr 22: 50.52 – 50.53 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr15:89255840-89258049">Chr 15: 89.26 – 89.26 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="PubMed" title="PubMed">PubMed</a> search</th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18034942" class="extiw external" title="d:Q18034942">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18318839" class="extiw external" title="d:Q18318839">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table>

<p><b>SCO2 cytochrome c oxidase assembly</b> (also known as <b>SCO2 homolog, mitochondrial</b> and <b>SCO cytochrome oxidase deficient homolog 2</b>) is a <a href="Protein" title="Protein">protein</a> that in humans is encoded by the <i>SCO2</i> <a href="Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid10218584_5-0" class="reference"><a href="#cite_note-pmid10218584-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16091356_6-0" class="reference"><a href="#cite_note-pmid16091356-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The encoded protein is one of the <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">cytochrome c oxidase (COX)</a>(Complex IV) assembly factors. Human <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">COX</a> is a multimeric <a href="Protein_complex" title="Protein complex">protein complex</a> that requires several assembly factors. <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Cytochrome c oxidase (COX)</a> <a href="Catalysis" title="Catalysis">catalyzes</a> the transfer of electrons from <a href="Cytochrome_c" title="Cytochrome c">cytochrome c</a> to <a href="Molecular_oxygen" class="mw-redirect" title="Molecular oxygen">molecular oxygen</a>, which helps to maintain the <a href="Proton_gradient" class="mw-redirect" title="Proton gradient">proton gradient</a> across the <a href="Inner_mitochondrial_membrane" title="Inner mitochondrial membrane">inner mitochondrial membrane</a> that is necessary for aerobic <a href="Adenosine_triphosphate" title="Adenosine triphosphate">ATP</a> production. The encoded protein is a <a href="Chaperone_(protein)" title="Chaperone (protein)">metallochaperone</a> that is involved in the biogenesis of <a href="Cytochrome_c_oxidase_subunit_II" class="mw-redirect" title="Cytochrome c oxidase subunit II">cytochrome c oxidase subunit II</a>. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and <a href="Myopia" title="Myopia">myopia</a> 6.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2></div>

<p>The <i>SCO2</i> gene is located on the <a href="Locus_(genetics)" title="Locus (genetics)">q arm</a> of <a href="Chromosome_22" title="Chromosome 22">chromosome 22</a> at position 13.33 and it spans 2,871 base pairs.<sup id="cite_ref-entrez_7-2" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The <i>SCO2</i> gene produces a 15.1 kDa protein composed of 136 <a href="Amino_acids" class="mw-redirect" title="Amino acids">amino acids</a>.<sup id="cite_ref-COPaKB_8-0" class="reference"><a href="#cite_note-COPaKB-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-url_COPaKB_9-0" class="reference"><a href="#cite_note-url_COPaKB-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The protein contains an <a href="N-terminal" class="mw-redirect" title="N-terminal">N-terminal</a> mitochondrial targeting presequence of 41 <a href="Amino_acids" class="mw-redirect" title="Amino acids">amino acids</a>, and shares identity with the <a href="Yeast" title="Yeast">yeast</a> protein in regions between <a href="Glycine" title="Glycine">glycine</a>-102 and <a href="Glycine" title="Glycine">glycine</a>-242 in human SCO2.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> SCO2 is a subunit of the enzyme <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Mammalian cytochrome c oxidase (COX)</a>(Complex IV).<sup id="cite_ref-entrez_7-3" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Function">Function</h2></div>

<p>The <i>SCO2</i> gene encodes for a <a href="Protein" title="Protein">protein</a> essential for the assembly and function of <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Mammalian cytochrome c oxidase (COX)</a>(Complex IV) of the <a href="Mitochondrial_respiratory_chain" class="mw-redirect" title="Mitochondrial respiratory chain">mitochondrial respiratory chain</a>. SCO2 acts as a <a href="Chaperone_(protein)" title="Chaperone (protein)">metallochaperone</a> involved in the <a href="Biogenesis" class="mw-redirect" title="Biogenesis">biogenesis</a> of <a href="Cytochrome_c_oxidase_subunit_II" class="mw-redirect" title="Cytochrome c oxidase subunit II">cytochrome c oxidase subunit II</a>, an essential subunit of <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Complex IV</a> which transfers the electrons from <a href="Cytochrome_c" title="Cytochrome c">cytochrome c</a> to the bimetallic center of the <a href="Cytochrome_c_oxidase_subunit_I" title="Cytochrome c oxidase subunit I">catalytic subunit 1</a> via its binuclear copper A center.<sup id="cite_ref-hehe_11-0" class="reference"><a href="#cite_note-hehe-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The biogenesis involves the transport of copper to the Cu(A) site on the <a href="Cytochrome_c_oxidase_subunit_II" class="mw-redirect" title="Cytochrome c oxidase subunit II">cytochrome c oxidase subunit II</a> leading to the proper synthesis and maturation of the subunit. In addition, SCO2 acts as a <a href="Thiol" title="Thiol">thiol</a>-<a href="Disulfide" title="Disulfide">disulfide</a> <a href="Oxidoreductase" title="Oxidoreductase">oxidoreductase</a> to regulate the redox state of the <a href="Cystein" class="mw-redirect" title="Cystein">cysteines</a> in <a href="SCO1" title="SCO1">SCO1</a> during maturation of the <a href="Cytochrome_c_oxidase_subunit_II" class="mw-redirect" title="Cytochrome c oxidase subunit II">cytochrome c oxidase subunit II</a>. The maturation and synthesis of <a href="Cytochrome_c_oxidase_subunit_II" class="mw-redirect" title="Cytochrome c oxidase subunit II">cytochrome c oxidase subunit II</a> is required for the function of <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Mammalian cytochrome c oxidase (COX)</a>(Complex IV).<sup id="cite_ref-uniprot0_12-0" class="reference"><a href="#cite_note-uniprot0-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-uniprot2_13-0" class="reference"><a href="#cite_note-uniprot2-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">Complex IV</a>, a multimeric <a href="Protein_complex" title="Protein complex">protein complex</a> that requires several assembly factors, <a href="Catalysis" title="Catalysis">catalyzes</a> the transfer of reducing equivalents from <a href="Cytochrome_c" title="Cytochrome c">cytochrome c</a> to molecular <a href="Oxygen" title="Oxygen">oxygen</a> and pumps <a href="Protons" class="mw-redirect" title="Protons">protons</a> across the <a href="Inner_mitochondrial_membrane" title="Inner mitochondrial membrane">inner mitochondrial membrane</a>.<sup id="cite_ref-entrez_7-4" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2></div>

<p>Mutations in <i>SCO2</i> that alter the regulation of <a href="Copper" title="Copper">copper</a> and <a href="Oxygen" title="Oxygen">oxygen</a> have been found to be associated with fatal infantile Cardioencephalomyopathy due to cytochrome c oxidase deficiency 1 (CEMCOX1), <a href="Myopia" title="Myopia">Myopia 6</a> (MYP6), and <a href="Leigh_syndrome" title="Leigh syndrome">Leigh syndrome</a> (LS).<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-uniprot0_12-1" class="reference"><a href="#cite_note-uniprot0-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> CEMCOX1 is characterized by disorders characterized by <a href="Hypotonia" title="Hypotonia">hypotonia</a>, <a href="Developmental_disability" title="Developmental disability">developmental delay</a>, <a href="Hypertrophic_cardiomyopathy" title="Hypertrophic cardiomyopathy">hypertrophic cardiomyopathy</a>, <a href="Lactic_acidosis" title="Lactic acidosis">lactic acidosis</a>, <a href="Gliosis" title="Gliosis">gliosis</a>, neuronal loss in <a href="Basal_ganglia" title="Basal ganglia">basal ganglia</a>, <a href="Brainstem" title="Brainstem">brainstem</a> and <a href="Spinal_cord" title="Spinal cord">spinal cord</a>, and <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">cytochrome c oxidase</a> deficiency. <a href="Myopia" title="Myopia">Myopia 6</a> is characterized by a <a href="Refraction" title="Refraction">refractive</a> error of the eye, in which parallel rays from a distant object come to focus in front of the <a href="Retina" title="Retina">retina</a>, vision being better for near objects than for far. Lastly, <a href="Leigh_syndrome" title="Leigh syndrome">leigh syndrome</a> is an early-onset progressive <a href="Neurodegeneration" class="mw-redirect" title="Neurodegeneration">neurodegenerative disorder</a> characterized by the presence of focal, bilateral <a href="Lesion" title="Lesion">lesions</a> in one or more areas of the <a href="Central_nervous_system" title="Central nervous system">central nervous system</a> including the <a href="Brainstem" title="Brainstem">brainstem</a>, <a href="Thalamus" title="Thalamus">thalamus</a>, <a href="Basal_ganglia" title="Basal ganglia">basal ganglia</a>, <a href="Cerebellum" title="Cerebellum">cerebellum</a> and <a href="Spinal_cord" title="Spinal cord">spinal cord</a>. Clinical manifestations may include <a href="Psychomotor_retardation" title="Psychomotor retardation">psychomotor retardation</a>, <a href="Hypotonia" title="Hypotonia">hypotonia</a>, <a href="Ataxia" title="Ataxia">ataxia</a>, weakness, <a href="Vision_loss" class="mw-redirect" title="Vision loss">vision loss</a>, <a href="Eye_movement" title="Eye movement">eye movement</a> abnormalities, <a href="Seizures" class="mw-redirect" title="Seizures">seizures</a>, and <a href="Dysphagia" title="Dysphagia">dysphagia</a>.<sup id="cite_ref-uniprot0_12-2" class="reference"><a href="#cite_note-uniprot0-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> A pathogenic mutation of G1541A in a patient has shown strong evidence in neonatal <a href="Hypotonia" title="Hypotonia">hypotonia</a> with an SMA 1 phenotype, and has been found to result in less <a href="Cytochrome_c_oxidase" title="Cytochrome c oxidase">COX</a> deficiencies.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> A mutation of 1602T>G has been found to result in rapidly progressive disease <a href="Phenotypes" class="mw-redirect" title="Phenotypes">phenotypes</a>.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Other pathogenic mutations have included a <a href="Missense_mutation" title="Missense mutation">missense mutation</a> of E140K, a <a href="Nonsense_mutation" title="Nonsense mutation">nonsense mutation</a> Q53X, and a 1541G > A mutation which resulted in a severe protein instability.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>

<p>In addition to co-complex interactions, SCO2 has been found to interact with <a href="COA6" title="COA6">COA6</a>, THEM177 in a <a href="COX20" title="COX20">COX20</a>-dependent manner, <a href="COX20" title="COX20">COX20</a>, COX16, <a href="SCO1" title="SCO1">SCO1</a>, and others.<sup id="cite_ref-uniprot0_12-3" class="reference"><a href="#cite_note-uniprot0-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

/* start https://en.wikipedia.org/ */

.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}

/* end https://en.wikipedia.org/ */

</style><div class="reflist">

<li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000284194">GRCh38: Ensembl release 89: ENSG00000284194</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

<li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000091780">GRCm38: Ensembl release 89: ENSMUSG00000091780</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

/* start https://en.wikipedia.org/ */

.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("./mw/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("./mw/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("./mw/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("./mw/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}

/* end https://en.wikipedia.org/ */

</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=9997">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite></span>

</li>

<li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=100126824">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite></span>

</li>

<li id="cite_note-pmid10218584-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10218584_5-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFParetOstermannKrause-BuchholzRentzsch1999" class="citation journal cs1">Paret C, Ostermann K, Krause-Buchholz U, Rentzsch A, Rödel G (March 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2899%2900266-5">"Human members of the SCO1 gene family: complementation analysis in yeast and intracellular localization"</a>. <i>FEBS Letters</i>. <b>447</b> (1): <span class="nowrap">65–</span>70. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2899%2900266-5">10.1016/S0014-5793(99)00266-5</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10218584">10218584</a>.</cite></span>

</li>

<li id="cite_note-pmid16091356-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16091356_6-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFHorngLearyCobineYoung2005" class="citation journal cs1">Horng YC, Leary SC, Cobine PA, Young FB, George GN, Shoubridge EA, Winge DR (October 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M506801200">"Human Sco1 and Sco2 function as copper-binding proteins"</a>. <i>The Journal of Biological Chemistry</i>. <b>280</b> (40): <span class="nowrap">34113–</span>22. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M506801200">10.1074/jbc.M506801200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16091356">16091356</a>.</cite></span>

</li>

<li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-entrez_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-entrez_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-entrez_7-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/9997">"Entrez Gene: SCO2 SCO2 cytochrome c oxidase assembly protein [ <i>Homo sapiens</i> (human) ]"</a>.</cite></span>

</li>

<cite id="CITEREFZongLiLiLam2013" class="citation journal cs1">Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076475">"Integration of cardiac proteome biology and medicine by a specialized knowledgebase"</a>. <i>Circulation Research</i>. <b>113</b> (9): <span class="nowrap">1043–</span>53. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2FCIRCRESAHA.113.301151">10.1161/CIRCRESAHA.113.301151</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076475">4076475</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23965338">23965338</a>.</cite></span>

</li>

<li id="cite_note-url_COPaKB-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-url_COPaKB_9-0">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://amino.heartproteome.org/web/protein/C9JBU1">"Protein SCO2 homolog, mitochondrial"</a>. <i>Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)</i>.</cite></span>

</li>

<li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><cite id="CITEREFPapadopoulouSueDavidsonTanji1999" class="citation journal cs1">Papadopoulou LC, Sue CM, Davidson MM, Tanji K, Nishino I, Sadlock JE, Krishna S, Walker W, Selby J, Glerum DM, Coster RV, Lyon G, Scalais E, Lebel R, Kaplan P, Shanske S, De Vivo DC, Bonilla E, Hirano M, DiMauro S, Schon EA (November 1999). "Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene". <i>Nature Genetics</i>. <b>23</b> (3): <span class="nowrap">333–</span>7. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F15513">10.1038/15513</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10545952">10545952</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23387553">23387553</a>.</cite></span>

</li>

<li id="cite_note-hehe-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-hehe_11-0">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P00403">"MT-CO2 - Cytochrome c oxidase subunit 2 - Homo sapiens (Human) - MT-CO2 gene & protein"</a>. <i>www.uniprot.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2018-07-31</span></span>.</cite><i><span typeof="mw:File"><a href="https://creativecommons.org/licenses/by/4.0/" title="creativecommons:by/4.0/" class="external"></a></span> This article incorporates [www.uniprot.org text] by UniProt available under the <a href="https://creativecommons.org/licenses/by/4.0/" class="extiw external" title="creativecommons:by/4.0/">CC BY 4.0</a> license.</i></span>

</li>

<li id="cite_note-uniprot0-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-uniprot0_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-uniprot0_12-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-uniprot0_12-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-uniprot0_12-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O43819">"SCO2 - Protein SCO2 homolog, mitochondrial precursor - Homo sapiens (Human) - SCO2 gene & protein"</a>. <i>www.uniprot.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2018-07-31</span></span>.</cite><i><span typeof="mw:File"><a href="https://creativecommons.org/licenses/by/4.0/" title="creativecommons:by/4.0/" class="external"></a></span> This article incorporates [www.uniprot.org text] by UniProt available under the <a href="https://creativecommons.org/licenses/by/4.0/" class="extiw external" title="creativecommons:by/4.0/">CC BY 4.0</a> license.</i></span>

</li>

<li id="cite_note-uniprot2-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-uniprot2_13-0">^</a></b></span> <span class="reference-text"><cite class="citation journal cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210571">"UniProt: the universal protein knowledgebase"</a>. <i>Nucleic Acids Research</i>. <b>45</b> (D1): <span class="nowrap">D158 –</span> <span class="nowrap">D169</span>. January 2017. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkw1099">10.1093/nar/gkw1099</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210571">5210571</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27899622">27899622</a>.</cite></span>

</li>

<cite id="CITEREFJakschParetStuckaHorn2001" class="citation journal cs1">Jaksch M, Paret C, Stucka R, Horn N, Müller-Höcker J, Horvath R, Trepesch N, Stecker G, Freisinger P, Thirion C, Müller J, Lunkwitz R, Rödel G, Shoubridge EA, Lochmüller H (December 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F10.26.3025">"Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts"</a>. <i>Human Molecular Genetics</i>. <b>10</b> (26): <span class="nowrap">3025–</span>35. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F10.26.3025">10.1093/hmg/10.26.3025</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11751685">11751685</a>.</cite></span>

</li>

<li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><cite id="CITEREFTarnopolskyBourgeoisFuKataeva2004" class="citation journal cs1">Tarnopolsky MA, Bourgeois JM, Fu MH, Kataeva G, Shah J, Simon DK, Mahoney D, Johns D, MacKay N, Robinson BH (March 2004). "Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype". <i>American Journal of Medical Genetics. Part A</i>. <b>125A</b> (3): <span class="nowrap">310–</span>4. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajmg.a.20466">10.1002/ajmg.a.20466</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14994243">14994243</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24732177">24732177</a>.</cite></span>

</li>

<li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><cite id="CITEREFKnufFaberHuthFreisinger2007" class="citation journal cs1">Knuf M, Faber J, Huth RG, Freisinger P, Zepp F, Kampmann C (January 2007). "Identification of a novel compound heterozygote SCO2 mutation in cytochrome c oxidase deficient fatal infantile cardioencephalomyopathy". <i>Acta Paediatrica</i>. <b>96</b> (1): <span class="nowrap">130–</span>2. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1651-2227.2007.00008.x">10.1111/j.1651-2227.2007.00008.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17187620">17187620</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20422657">20422657</a>.</cite></span>

</li>

<li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><cite id="CITEREFSalviatiSacconiRasalanKronn2002" class="citation journal cs1">Salviati L, Sacconi S, Rasalan MM, Kronn DF, Braun A, Canoll P, Davidson M, Shanske S, Bonilla E, Hays AP, Schon EA, DiMauro S (May 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchneur.59.5.862">"Cytochrome c oxidase deficiency due to a novel SCO2 mutation mimics Werdnig-Hoffmann disease"</a>. <i>Archives of Neurology</i>. <b>59</b> (5): <span class="nowrap">862–</span>5. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchneur.59.5.862">10.1001/archneur.59.5.862</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12020273">12020273</a>.</cite></span>

</li>

<li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><cite id="CITEREFTayShanskeKaplanDiMauro2004" class="citation journal cs1">Tay SK, Shanske S, Kaplan P, DiMauro S (June 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchneur.61.6.950">"Association of mutations in SCO2, a cytochrome c oxidase assembly gene, with early fetal lethality"</a>. <i>Archives of Neurology</i>. <b>61</b> (6): <span class="nowrap">950–</span>2. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchneur.61.6.950">10.1001/archneur.61.6.950</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15210538">15210538</a>.</cite></span>

</li>

<li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><cite id="CITEREFJoostRodenburgPiirsoovan_den_Heuvel2010" class="citation journal cs1">Joost K, Rodenburg R, Piirsoo A, van den Heuvel B, Zordania R, Ounap K (March 2010). "A novel mutation in the SCO2 gene in a neonate with early-onset cardioencephalomyopathy". <i>Pediatric Neurology</i>. <b>42</b> (3): <span class="nowrap">227–</span>30. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pediatrneurol.2009.10.004">10.1016/j.pediatrneurol.2009.10.004</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20159436">20159436</a>.</cite></span>

</li>

<cite id="CITEREFKerrienAlam-FaruqueArandaBancarz2007" class="citation journal cs1">Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R, Kohler C, Khadake J, Leroy C, Liban A, Lieftink C, Montecchi-Palazzi L, Orchard S, Risse J, Robbe K, Roechert B, Thorneycroft D, Zhang Y, Apweiler R, Hermjakob H (January 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751531">"IntAct--open source resource for molecular interaction data"</a>. <i>Nucleic Acids Research</i>. <b>35</b> (Database issue): D561–5. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkl958">10.1093/nar/gkl958</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751531">1751531</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17145710">17145710</a>.</cite></span>

</li>

</ol></div></div>

<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>

/* start https://en.wikipedia.org/ */

.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}

/* end https://en.wikipedia.org/ */

</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em">

<ul><li><cite id="CITEREFJakschOgilvieYaoKortenhaus2000" class="citation journal cs1">Jaksch M, Ogilvie I, Yao J, Kortenhaus G, Bresser HG, Gerbitz KD, Shoubridge EA (March 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F9.5.795">"Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency"</a>. <i>Human Molecular Genetics</i>. <b>9</b> (5): <span class="nowrap">795–</span>801. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F9.5.795">10.1093/hmg/9.5.795</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10749987">10749987</a>.</cite></li>

<li><cite id="CITEREFJakschHorvathHornAuer2001" class="citation journal cs1">Jaksch M, Horvath R, Horn N, Auer DP, Macmillan C, Peters J, Gerbitz KD, Kraegeloh-Mann I, Muntau A, Karcagi V, Kalmanchey R, Lochmuller H, Shoubridge EA, Freisinger P (October 2001). "Homozygosity (E140K) in SCO2 causes delayed infantile onset of cardiomyopathy and neuropathy". <i>Neurology</i>. <b>57</b> (8): <span class="nowrap">1440–</span>6. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1212%2Fwnl.57.8.1440">10.1212/wnl.57.8.1440</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11673586">11673586</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24920023">24920023</a>.</cite></li>

<li><cite id="CITEREFJakschParetStuckaHorn2001" class="citation journal cs1">Jaksch M, Paret C, Stucka R, Horn N, Müller-Höcker J, Horvath R, Trepesch N, Stecker G, Freisinger P, Thirion C, Müller J, Lunkwitz R, Rödel G, Shoubridge EA, Lochmüller H (December 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F10.26.3025">"Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts"</a>. <i>Human Molecular Genetics</i>. <b>10</b> (26): <span class="nowrap">3025–</span>35. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F10.26.3025">10.1093/hmg/10.26.3025</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11751685">11751685</a>.</cite></li>

<li><cite id="CITEREFSalviatiHernandez-RosaWalkerSacconi2002" class="citation journal cs1">Salviati L, Hernandez-Rosa E, Walker WF, Sacconi S, DiMauro S, Schon EA, Davidson MM (April 2002). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222481">"Copper supplementation restores cytochrome c oxidase activity in cultured cells from patients with SCO2 mutations"</a>. <i>The Biochemical Journal</i>. <b>363</b> (Pt 2): <span class="nowrap">321–</span>7. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2F0264-6021%3A3630321">10.1042/0264-6021:3630321</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222481">1222481</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11931660">11931660</a>.</cite></li>

<li><cite id="CITEREFCollinsGowardColeSmink2003" class="citation journal cs1">Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (January 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC430954">"Reevaluating human gene annotation: a second-generation analysis of chromosome 22"</a>. <i>Genome Research</i>. <b>13</b> (1): <span class="nowrap">27–</span>36. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.695703">10.1101/gr.695703</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC430954">430954</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12529303">12529303</a>.</cite></li>

<li><cite id="CITEREFSacconiSalviatiSueShanske2003" class="citation journal cs1">Sacconi S, Salviati L, Sue CM, Shanske S, Davidson MM, Bonilla E, Naini AB, De Vivo DC, DiMauro S (February 2003). "Mutation screening in patients with isolated cytochrome c oxidase deficiency". <i>Pediatric Research</i>. <b>53</b> (2): <span class="nowrap">224–</span>30. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1203%2F01.PDR.0000048100.91730.6A">10.1203/01.PDR.0000048100.91730.6A</a>. <a href="Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/11577%2F1368344">11577/1368344</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12538779">12538779</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:12496207">12496207</a>.</cite></li>

<li><cite id="CITEREFBrandenbergerWeiZhangLei2004" class="citation journal cs1">Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". <i>Nature Biotechnology</i>. <b>22</b> (6): <span class="nowrap">707–</span>16. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnbt971">10.1038/nbt971</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15146197">15146197</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27764390">27764390</a>.</cite></li>

<li><cite id="CITEREFLearyKaufmanPellecchiaGuercin2004" class="citation journal cs1">Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M, Shoubridge EA (September 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2Fddh197">"Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase"</a>. <i>Human Molecular Genetics</i>. <b>13</b> (17): <span class="nowrap">1839–</span>48. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2Fddh197">10.1093/hmg/ddh197</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15229189">15229189</a>.</cite></li>

<li><cite id="CITEREFCollinsWrightEdwardsDavis2005" class="citation journal cs1">Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604">"A genome annotation-driven approach to cloning the human ORFeome"</a>. <i>Genome Biology</i>. <b>5</b> (10): R84. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fgb-2004-5-10-r84">10.1186/gb-2004-5-10-r84</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545604">545604</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15461802">15461802</a>.</cite></li>

<li><cite id="CITEREFStiburekVeselaHansikovaPecina2005" class="citation journal cs1">Stiburek L, Vesela K, Hansikova H, Pecina P, Tesarova M, Cerna L, Houstek J, Zeman J (December 2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316303">"Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1"</a>. <i>The Biochemical Journal</i>. <b>392</b> (Pt 3): <span class="nowrap">625–</span>32. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2FBJ20050807">10.1042/BJ20050807</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316303">1316303</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16083427">16083427</a>.</cite></li>

<li><cite id="CITEREFMatobaKangPatinoWragg2006" class="citation journal cs1">Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM (June 2006). "p53 regulates mitochondrial respiration". <i>Science</i>. <b>312</b> (5780): <span class="nowrap">1650–</span>3. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2006Sci...312.1650M">2006Sci...312.1650M</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1126863">10.1126/science.1126863</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16728594">16728594</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:36668814">36668814</a>.</cite></li>

<li><cite id="CITEREFLearyCobineKaufmanGuercin2007" class="citation journal cs1">Leary SC, Cobine PA, Kaufman BA, Guercin GH, Mattman A, Palaty J, Lockitch G, Winge DR, Rustin P, Horvath R, Shoubridge EA (January 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cmet.2006.12.001">"The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis"</a>. <i>Cell Metabolism</i>. <b>5</b> (1): <span class="nowrap">9–</span>20. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cmet.2006.12.001">10.1016/j.cmet.2006.12.001</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17189203">17189203</a>.</cite></li>

<li><cite id="CITEREFBanciBertiniCiofi-BaffoniGerothanassis2007" class="citation journal cs1">Banci L, Bertini I, Ciofi-Baffoni S, Gerothanassis IP, Leontari I, Martinelli M, Wang S (September 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.str.2007.07.011">"A structural characterization of human SCO2"</a>. <i>Structure</i>. <b>15</b> (9): <span class="nowrap">1132–</span>40. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.str.2007.07.011">10.1016/j.str.2007.07.011</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17850752">17850752</a>.</cite></li></ul>

</div>

<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

<ul><li><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=SCO2"><i>SCO2</i></a> human gene location in the <a href="UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li>

<li><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=SCO2"><i>SCO2</i></a> human gene details in the <a href="UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul></div><div><div class="zim-footer">

This article is issued from <a class="external text" title="Last edited on 2025-07-18" href="https://en.wikipedia.org/wiki/?title=SCO2&oldid=1301121602">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.

</div>

</div></div>

</div>

</main>

</div>

</body></html>